Lab of Dr Marcus Kaiser and his team as part of the Interdisciplinary Computing and Complex BioSystems (ICOS) research group. We are working on the simulation of the dynamics and development of neural networks using Neuroinformatics and network analysis tools. We aim to understand the link between structure and dynamics (e.g. for epilepsy or other network diseases) and to find structural correlates of robustness and functional compensation. We are part of the Neuroinformatics@Newcastle network and are leading the Human Green Brain Project on modelling human brain development.
To understand the development of networks leading to normal and pathological (e.g. epileptic) dynamics, we observe the role of different factors using computer simulations (Kaiser et al. Cerebral Cortex 2009; Varier and Kaiser PLoS Comp Biol 2011; Lim et al. Cerebral Cortex 2014).
We developed a detailed simulation of resected cortical tissue that can reproduce experimentally recorded local field potentials as a started point to study stimulation and pharmacological intervention in a computational model of human brain function (Tomsett et al. Brain Structure and Function 2014).